Table 2.

Univariable and Multivariable Cox proportional hazards models of factors associated with recurrence free survival (RFS) in patients with resected pathologic III cutaneous melanoma receiving adjuvant immune checkpoint inhibitors (ICI). The adjusted multivariable model includes Age, Histology, Primary Tumor Location, Pathologic Stage, Nodal Burden (mm), Adjuvant Radiation, and Time to Adjuvant ICI. Pathologic stage incorporates clinical stage and nodes positive, to limit multicollinearity these variables were not included in the multivariable model. Complete case analysis was used with 464 complete cases with 203 recurrence events.

Variable	Unadjusted Models			Adjusted Model
	HR	95% CI	p-value	HR	95% CI	p-value
Age (per 5 years)	1.08	1.04–1.13	<0.001	1.07	1.02–1.13	<0.01
Insurance Status (ref: none)
Government	1.09	0.62–1.94	0.76
Private	0.78	0.44–1.38	0.40
Coordinated Care (ref: fragmented)	1.01	0.78–1.31	0.94
Histology (ref: superficial spreading)
Nodular	1.05	0.76–1.47	0.76	0.81	0.56–1.18	0.27
Acral	1.74	1.16–2.60	0.01	1.23	0.73–2.07	0.43
Other	0.95	0.71–1.27	0.70	0.83	0.56–1.22	0.34
Primary Tumor Location (ref: head/neck)
Trunk	1.38	0.94–2.02	0.10	1.82	1.13–2.92	0.01
Upper Extremity	1.13	0.75–1.71	0.56	1.38	0.82–2.32	0.23
Lower Extremity	1.43	0.98–2.10	0.07	1.58	0.94–2.67	0.09
Unknown Primary	0.56	0.30–1.03	0.06	0.30	0.11–0.80	0.02
Pathologic Stage (ref: IIIA)
IIIB	1.87	1.06–3.30	0.03	1.58	0.84–3.00	0.16
IIIC	2.48	1.44–4.28	<0.01	2.23	1.21–4.10	0.01
IIID	5.90	2.80–12.43	<0.001	4.91	2.15–11.24	<0.001
Nodal Tumor Burden (per mm)	1.00	0.99–1.01	0.99	1.01	1.00–1.02	0.02
Nodes Positive (per node)	1.05	0.99–1.11	0.12
Adjuvant Radiation (ref: none)	1.03	0.68–1.57	0.89	1.43	0.85–2.41	0.18
Time to Adjuvant ICI (per week)	0.96	0.93–0.98	<0.001	0.96	0.93–0.99	0.01