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. Author manuscript; available in PMC: 2023 Sep 27.
Published in final edited form as: Neurobiol Dis. 2023 Aug 8;185:106257. doi: 10.1016/j.nbd.2023.106257

Fig. 4.

Fig. 4.

Tet1 Deficiency Alters 5xFAD-associated Epigenetic Landscapes.

A) Variation in the loss and gain of DhMR between 5xFAD (n = 2) and 5xFAD/Tet1(+/−) (n = 4) mice. There is a loss of 3977 DhMRs and a gain of 40 DhMRs in the 5xFAD/Tet1(+/−) mice relative to 5xFAD. B) RPM normalized abundance of 5hmC modifications at Enhancer, Gene body, TSS, and Exon acceptor and donor sites. C) DNA binding motif analysis for HIF-1b, HIF-1a, and HIF-2a for all DhMRs. D) Gene ontology analysis of all DhMRs between 5xFAD and 5xFAD/Tet1(+/−).