Table 2b.
Multivariable Analysis for Overall Survival
| Measure | Overall Survival | |
|---|---|---|
| Hazard Ratio (95% CI) | p-Value | |
| Age at autoHCT (years) | ||
| >70 vs. ≤70 | 1.17 (0.84, 1.63) | 0.34 |
| Cytogenetic risk | ||
| High vs. Standard | 1.77 (1.30, 2.41) | <0.001 |
| R-ISS | ||
| II vs. I | 1.31 (0.93, 1.85) | 0.13 |
| III vs. I | 2.73 (1.62, 4.58) | <0.001 |
| HCT-CI Score | ||
| > 3 vs. ≤ 3 | 1.85 (1.39, 2.45) | <0.001 |
| Maintenance duration a | ||
| >3 years vs. ≤3 years | 0.19 (0.14, 0.26) | <0.001 |
| Reason for maintenance d/c a | ||
| Fatigue vs. Other | 0.09 (0.01, 0.68) | 0.019 |
Abbreviations: CI=Confidence interval, ref=Reference, AutoHCT=Autologous stem cell transplant, R-ISS= Revised International multiple myeloma staging system, KRD= Carfilzomib/Revlimid/dexamethasone, HCT-CI=Hematopoietic Cell Transplantation-specific Comorbidity Index, MRD=Minimal residual disease, VGPR=Very good partial response, CR=Complete response, d/c=discontinuation.
a
Included in the model as a time-dependent covariate