Table 5.
Trabecular microstructure and cortical geometry from microCT analysis. All p-values correspond with results of the omnibus ANOVA test unless specifically indicated with symbol # which indicates a pairwise post-hoc test following a significant interaction.
| Properties | Female | Male | ||
|---|---|---|---|---|
| Conventional n = 10 |
GF n = 6 |
Conventional n = 10 |
GF n = 7 |
|
| Trabecular microarchitecture | ||||
|
BV/TV (%) GF: p = 0.051 Sex: p < 0.001 GF x sex: p = 0.67 Body mass: p = 0.17 |
6.51 ± 1.10 | 7.83 ± 2.35 | 18.12 ± 0.89 | 20.15 ± 2.69 |
|
BMD (mgHA/cm3) GF: p = 0.051 Sex: p < 0.001 GF x sex: p = 0.76 Body mass: p = 0.28 |
130.82 ± 10.83 | 142.08 ± 17.19 | 222.51 ± 23.33 | 237.73 ± 19.08 |
|
Conn.D (1/mm3) GF x sex: p < 0.001 Body mass: p = 0.97 |
33.82 ± 8.71 | 39.75 ± 18.04 | 99.88 ± 11.30 | 178.98 ± 16.56 # p < 0.001, +79.1% |
|
SMI GF: p = 0.10 Sex: p < 0.001 GF x sex: p = 0.85 Body mass: p = 0.027 |
3.08 ± 0.25 | 3.05 ± 0.28 | 1.54 ± 0.37 | 1.67 ± 0.30 |
|
Tb.Th (mm) GF x sex: p < 0.001 Body mass: p = 0.26 |
0.0515± 0.0039 | 0.0559 ± 0.0059 | 0.0590 ± 0.0045 | 0.0513 ± 0.0027 # p =0.001, −13.0% |
|
Tb.N (1/mm) GF x sex: p < 0.001 Body mass: p = 0.56 |
3.02 ± 0.25 | 3.21 ± 0.17 | 4.25 ± 0.22 | 5.35 ± 0.23 # p < 0.001, +25.6% |
|
Tb.Sp (mm) GF x sex: p < 0.001 Body mass: p = 0.57 |
0.33 ± 0.03 | 0.31 ± 0.02 | 0.23 ± 0.01 | 0.18 ± 0.01 # p < 0.001, −22.9% |
| Cortical microarchitecture | ||||
|
Imin
(mm4) Sex x GF: p < 0.001 Body mass: p < 0.001 |
0.119 ± 0.0127 | 0.130 ± 0.00036 #p =0.04, +9.0% |
0.198 ± 0.0260 | 0.129 ± 0.0106 #p <0.001, −34.8% |
|
Section modulus (mm3) Sex x GF: p < 0.001 Body mass: p < 0.001 |
0.196 ± 0.0178 | 0.199 ± 0.0057 #p =0.021, +1.5% |
0.280 ± 0.0297 | 0.204 ± 0.0126 #p <0.001, −27.1% |
|
pMOI (mm4) Sex x GF: p = 0.004 Body mass: p < 0.001 |
0.389 ± 0.061 | 0.397 ± 0.064 | 0.630 ± 0.093 | 0.411 ± 0.033 #p <0.001, −36.5% |
|
Ct. Area (mm2) GF: p < 0.001 Sex: p = 0.07 Sex x GF: p = 0.06 Body mass: p < 0.001 |
0.853 ± 0.074 | 0.834 ± 0.016 | 0.971 ± 0.078 | 0.818 ± 0.044 |
|
Ct. Th (mm) GF: p = 0.27 Sex: p < 0.001 GF x sex: p = 0.74 Body mass: p = 0.049 |
0.197 ± 0.011 | 0.195 ± 0.018 | 0.179 ± 0.009 | 0.175 ± 0.008 |
|
Ct. TMD (mgHA/cm3) GF: p = 0.003 Sex: p < 0.001 GF x sex: p = 0.91 Body mass: p = 0.78 |
1244.00 ± 10.50 | 1229.60 ± 20.0 | 1198.80 ± 9.76 | 1185.40 ± 1.93 |
Data are presented as mean ± standard deviation. # = significantly different from conventional mice of same sex. In the case of a significant interaction, main effects are not reported.