Table 2.
Clinical importance and functional analysis of Piezo1 in different cancer types.
| Cancer Type | Expression | Function | Clinical Features | Molecular Mechanism |
References |
|---|---|---|---|---|---|
| Breast | Upregulated | Migration, invasion. |
Poor overall survival. | Mechanical stress sensor. Actin protrusion formation via Src. Bleb-driven cell migration attenuation. |
[101,102,103,104] |
| Glioma | Upregulated | Proliferation, migration, invasion, angiogenesis. |
Glioblastoma aggravation, poor prognosis. | ECM remodeling. | [105,106,107] |
| Prostate | Upregulated | Proliferation, migration, invasion. |
Poor overall survival. | Akt/mTOR signaling activation. Src/YAP signaling activation. |
[108,109] |
| Gastric | Upregulated | Proliferation, migration, invasion, angiogenesis. |
Poor overall survival. | TFF1 inhibition. RhoA and Rac1 activation Calpain1/2 activation via HIF-1α upregulation. |
[110,111,112] |
| Liver | Upregulated | Migration, invasion, angiogenesis. |
Poor clinical outcomes. | TGF-β activation via Rac5c. YAP activation in a Hippo-independent signaling mechanism. Mechanical stress sensor. |
[113,114] |