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. Author manuscript; available in PMC: 2024 Jul 31.
Published in final edited form as: Vaccine. 2023 Jul 6;41(34):4996–5002. doi: 10.1016/j.vaccine.2023.06.081

Figure 1. mRNA-LNP screening: Tick feeding kinetics on guinea pigs immunized with LNPs containing a single mRNA.

Figure 1.

Guinea pigs were immunized three times with a single mRNA-LNP (A-C) and challenged with 30 Ixodes scapularis nymphs. Evidence of tick rejection and the tick feeding kinetics were monitored for the duration of the experiment and the graph shows the percentage of ticks that remain attached, and the detachment at a given time point (A). The success of tick feeding was determined by examining engorgement weights of the recovered ticks (B). Erythema at each tick bite site was calculated as the percent of nymphs (30 per animal as 100%) showing redness on each animal (C). One animal (n=1) was used for each mRNA, totaling 12 animals.