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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: Cancer Immunol Res. 2023 Sep 1;11(9):1222–1236. doi: 10.1158/2326-6066.CIR-22-0254

Figure 6: CART19-cell transcriptomic changes following AXL inhibition.

Figure 6:

A, CART19 cells were incubated with lethally irradiated JeKo-1 cells in the presence of TP-0903 (10–30 nM) at a 1:3 ratio for 24 hours. After the incubation, T cells were enriched and assessed via western blotting for changes in AXL downstream signaling pathways. B, Principal component analysis (PCA) of RNA-seq data from CART19 cells with/without 30 nM of TP-0903. C-D, Volcano plot and heatmap showing differential expression of transcripts in TP-0903-treated CART19 cells compared to untreated (DMSO) CART19 cells.