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. Author manuscript; available in PMC: 2024 Aug 23.
Published in final edited form as: J Am Chem Soc. 2023 Aug 9;145(33):18676–18683. doi: 10.1021/jacs.3c06734

Scheme 3.

Scheme 3.

Proposed mechanism for regio- and enantioselective ruthenium-SEGPHOS-catalyzed isoprene-mediated tert-prenylation of primary alcohols as corroborated by deuterium labelling.a

aThe extent of deuterium incorporation was corroborated 1H, 2H NMR and HRMS. See Supporting Information for further details.