Table 2.

Comparison of PROs by stage of disease using Mayo 2004 stage at the time of survey completion. Significant values are shown in bold

Domain	Measure	Stage I N=33	Stage II N=37	Stage III N=31	Cohen’s d III vs I	p- value*
Physical Function	PROMIS Physical Function-4	46.7	43.2	40.4	−0.76 (−1.26, −0.25)	0.01
	SF-36 Physical Functioning	49.3	46.5	42.2	−0.76 (−1.28, −0.25)	0.01
	SF-36 Role Physical	49.7	45.4	44.4	−0.52 (−1.03, 0.00)	0.10
	KCCQ-12 Physical Limitations	72.6	66.1	68.4	−0.19 (−0.87, 0.50)	0.7
Fatigue	PROMIS Fatigue-4	50.7	53.4	56.8	0.61 (0.11, 1.12)	0.05
	PROMIS Fatigue-8	51.2	53.4	57.5	0.64 (0.13, 1.14)	0.04
	SF-36 Vitality	48.8	46.4	44.4	−0.40 (−0.90, 0.11)	0.3
	KCCQ-12 Item 3	4.1	4.4	3.8	−0.16 (−0.84; 0.51)	0.5
Social Roles	PROMIS Ability to Perform Social Roles and Activities	51.0	47.2	44.9	−0.68 (−1.19, −0.18)	0.03
	SF-36 Social Function	49.7	47.7	44.6	−0.55 (−1.06, −0.04)	0.1
	KCCQ-12 Social Limitations	76.2	64.4	62.0	−0.54 (−1.22, 0.15)	0.3
Pain	PROMIS Pain Interference	47.7	51.5	51.7	0.42 (−0.08, 0.93)	0.2
	SF-36 Bodily Pain	54.7	50.4	52.2	−0.27 (−0.78, 0.23)	0.2
Sleep	PROMIS Sleep Disturbance	50.5	51.3	49.5	−0.10 (−0.60, 0.40)	0.8
Mental Health	PROMIS Anxiety	50.3	51.6	51.1	0.09 (−0.40, 0.59)	0.8
	PROMIS Depression	46.9	49.9	48.3	0.18 (−0.31, 0.68)	0.3
	PROMIS Cognitive Function	53.1	53.9	51.2	−0.25 (−0.76, 0.25)	0.3
	SF-36 Mental Health	54.9	53.4	53.4	−0.21 (−0.71, 0.30)	0.6
	SF-36 Role Emotional	52.5	51.4	48.4	−0.42 (−0.93, 0.09)	0.2
Summary scores and Other	PROMIS GPSS	47.4	43.2	41.6	−0.64 (−1.15, −0.13)	0.04
	PROMIS GMSS	51.8	47.3	46.9	−0.51 (−1.02, −0.01)	0.08
	SF-36 PCS	50.1	45.4	44.6	−0.62 (−1.14, −0.11)	0.03
	SF-36 MCS	51.8	49.2	48.2	−0.45 (−0.96, 0.06)	0.2
	SF-36 General Health	47.8	41.2	43.3	−0.45 (−0.96, 0.06)	0.03
	KCCQ-12 Total	73.3	67.2	64.6	−0.40 (−1.08, 0.28)	0.5
	KCCQ-12 Symptoms	73.1	72.2	68.3	−0.21 (−0.89, 0.47)	0.8
	KCCQ-12 Quality of Life	71.4	64.7	59.8	−0.40 (−1.08, 0.28)	0.5

^*One-way ANOVA