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. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Hypertension. 2023 Aug 18;80(10):2072–2087. doi: 10.1161/HYPERTENSIONAHA.123.21392

Figure 5. The age-related plasma proteome is mediated, in part, by cellular senescence and related to changes in nitric oxide (NO)-mediated endothelium-dependent dilation (EDD).

Figure 5.

(A) Relative plasma protein changes that were related to post-intervention NO-mediated EDD. (B) Plasma proteins that were relatively: i) higher with aging; ii) lower with GCV treatment; iii) positively related to post-intervention NO-mediated EDD; and iv) accepted as senescence-associated secretory phenotype (SASP) proteins. (C) KEGG pathway analyses of the 21 proteins that met the criteria presented in Figure 5B. Data are mean ± SEM. n = 10/group (Young Vehicle; Old Vehicle; Old GCV).