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. Author manuscript; available in PMC: 2024 Aug 17.
Published in final edited form as: Cell Chem Biol. 2023 Jul 17;30(8):893–905.e7. doi: 10.1016/j.chembiol.2023.06.013

Figure 5. PSGL-1 sulfopeptide inhibits chemotaxis of primary human dendritic cells.

Figure 5.

Chemotaxis by primary human dendritic cells towards CCL19 and CCL21 measured using transwell inserts. Migration without any PSGL-1 peptide added was set to 100% and compared to migration with hPSGL-1 sulfopeptide (14) or unmodified peptide (1). Incubation with sulfopeptide shows clear reduction of the chemotactic index for both CCL19 and CCL21. Unmodified peptide also inhibited chemotaxis towards CCL19, to a smaller degree than the sulfated peptide, ns = not significant; * = P ≤ 0.05, *** = P ≤ 0.001. 2 biological replicates with 2 technical replicates.