Effects of trans-nonachlor in LFD or HFD on weight gain, food intake, and average daily trans-nonachlor exposure. Male Sprague Dawley rats were fed either LFD or HFD with 0, .5 or 5 ppm of trans-nonachlor for 16 weeks. Body weights (A), food intake (B), and average daily trans-nonachlor exposure (C) on a mg/kg body weight basis were determined on a weekly basis. Data represents the mean ± SEM of n = 9 animals/group. #P ≤ .05 vs the corresponding dose of trans-nonachlor in LFD.