Expression of inflammatory mediators in the livers of trans-nonachlor exposed LFD or HFD fed animals. Hepatic expression of the inflammatory mediators F4/80, a monocyte/ macrophage marker, and IL-1β, a pro-inflammatory cytokine, were measured following 16 weeks of LFD or HFD intake with 0, .5 or 5 ppm of trans-nonachlor to assess hepatic inflammatory status. Data are expressed as the fold change from LFD + 0 ppm and represent the mean ± SEM of 5–6 animals/group. #P ≤ .05 vs the corresponding dose of trans-nonachlor in LFD, &P ≤ .05 vs 0 ppm exposed HFD animals.