Table 2.
Summary of CCRF-CEM and Jurkat Top 15 Synergy Scores per Model via Combenefit and SynergyFinder Plus. Cytarabine and adavosertib concentrations are shown in the first two rows of each leukemic cell line. The rows indicate the different synergy scores per synergy model and the mean synergy score is shown in the bottom row. The highest mean synergy score across all models is shown in bold and corresponds to 63 nM cytarabine with 97 nM adavosertib in Jurkat.
| CCRF-CEM | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cytarabine (nM) | 84 | 84 | 84 | 84 | 45 | 45 | 45 | 45 | 24 | 24 | 24 | 13 | 13 | 7 | 7 |
| adavosertib (nM) | 30 | 48 | 75 | 119 | 30 | 48 | 75 | 119 | 48 | 75 | 119 | 75 | 119 | 75 | 119 |
| Models | Combenefit Synergy Score (%) | ||||||||||||||
| Loewe | 14 | 17 | 12 | 6 | 4 | 21 | 20 | 10 | 2 | 21 | 12 | 7 | 12 | −17 | 8 |
| Bliss | 32 | 36 | 25 | 10 | 27 | 48 | 40 | 17 | 22 | 38 | 18 | 18 | 16 | −11 | 10 |
| HSA | 34 | 45 | 48 | 21 | 31 | 62 | 50 | 21 | 26 | 40 | 19 | 18 | 17 | −11 | 10 |
| Mean Score | 26.7 | 32.7 | 28.3 | 12.3 | 20.7 | 43.7 | 36.7 | 16 | 16.7 | 33 | 16.3 | 14.3 | 15 | −13 | 9.3 |
| Models | SynergyFinder Plus Synergy Score (%) | ||||||||||||||
| Loewe | 16.3 | 17.3 | 10.4 | 3.2 | 17.8 | 30.2 | 23.1 | 7.1 | 17 | 36.4 | 10.8 | 30.3 | 11.9 | 10.1 | 10.3 |
| Bliss | 33.5 | 42.9 | 42.9 | 13.2 | 27.8 | 54.1 | 66 | 21.2 | 22.8 | 65.5 | 22 | 45.8 | 19.08 | 15.8 | 13.8 |
| HSA | 38.7 | 50.1 | 53.1 | 24.9 | 35.4 | 63.4 | 76.4 | 24.8 | 28.4 | 70.8 | 23.6 | 49.6 | 20.3 | 29.8 | 15.3 |
| ZIP | 36.6 | 46 | 42.2 | 13.4 | 28.9 | 60.2 | 64.7 | 21.1 | 26.6 | 64.5 | 22.5 | 44.5 | 20.4 | 15.5 | 14.1 |
| Mean Score | 31.3 | 39.1 | 37.2 | 13.7 | 27.5 | 52 | 57.6 | 18.6 | 23.7 | 59.3 | 19.7 | 42.6 | 17.9 | 17.8 | 13.4 |
| Jurkat | |||||||||||||||
| cytarabine (nM) | 63 | 125 | 31 | 63 | 125 | 16 | 31 | 63 | 125 | 4 | 8 | 16 | 31 | 63 | 125 |
| adavosertib (nM) | 58 | 58 | 97 | 97 | 97 | 162 | 162 | 162 | 162 | 270 | 270 | 270 | 270 | 270 | 270 |
| Models | Combenefit Synergy Score (%) | ||||||||||||||
| Loewe | 61 | 59 | 50 | 85 | 48 | 46 | 84 | 76 | 30 | 24 | 56 | 73 | 64 | 36 | 12 |
| Bliss | 63 | 75 | 50 | 91 | 78 | 47 | 88 | 95 | 79 | 26 | 61 | 83 | 89 | 88 | 73 |
| HSA | 63 | 75 | 50 | 91 | 78 | 47 | 88 | 95 | 79 | 26 | 61 | 83 | 89 | 89 | 79 |
| Mean Score | 62.3 | 69.7 | 50.0 | 89.0 | 68.0 | 46.7 | 86.7 | 88.7 | 62.7 | 25.3 | 59.3 | 79.7 | 80.7 | 71.0 | 54.7 |
| Models | SynergyFinder Plus Synergy Score (%) | ||||||||||||||
| ZIP | 64.9 | 74.9 | 53.7 | 90.4 | 78.3 | 48.2 | 89.3 | 94.6 | 79.3 | 28.6 | 60.6 | 82.5 | 87.8 | 88.1 | 73.8 |
| Loewe | 62.5 | 58.9 | 52.6 | 84.7 | 45.7 | 46.7 | 84.7 | 54 | 22.2 | 26.7 | 55 | 73.1 | 32.1 | 14.1 | 8.4 |
| Bliss | 65.2 | 74.9 | 53.6 | 90.7 | 78.3 | 48.2 | 88.6 | 95.6 | 79.3 | 28.8 | 59.5 | 83.1 | 88.5 | 88.5 | 73.8 |
| HSA | 65.1 | 74.9 | 53.6 | 90.6 | 78.3 | 48.2 | 88.6 | 95.5 | 79.3 | 28.8 | 59.5 | 83.1 | 88.5 | 88.7 | 79.8 |
| Mean Score | 64.4 | 70.9 | 53.4 | 89.1 | 70.2 | 47.8 | 87.8 | 84.9 | 65 | 28.2 | 58.6 | 80.5 | 74.2 | 69.9 | 58.9 |