The figure depicts axial, coronal, and sagittal views of significant differences in white matter volumes between healthy bipolar offspring and healthy control offspring encompassing right frontal lobe, and right and left parietal lobes. Healthy bipolar offspring presented with decreased white matter volumes than healthy control offspring. The level of statistically significant differences in white matter volumes between groups was defined as p<0.05, FDR-corrected, with a cluster size of >35.