Figure 4.

(A) DT pairs hyperbolically close, inhibited by the same class of drugs, and involved in the same pathways, processes, or complexes. The colored ellipses represent DT pairs or groups targeted by the same drugs, for example, ribosomal proteins participating in protein synthesis inhibited by linezolid and sutezolid; similarly, DT pairs part of the RNA polymerase complex targeted by rifampicin and its derivatives. (B) DT pairs that are components of the same pathways and are inhibited by two different classes of drugs. Drug classes and gene symbols are indicated—cluster colors as in Figure 1.