Table 1.
List of DT pairs arranged in increasing hyperbolic distance involved in the same metabolic pathways and inhibited by the same class of drugs.
| DT_a DT_b | dH2 | Pathway of DT_a | Pathway of DT_b | Common Drug |
|---|---|---|---|---|
| embB/embA | 4.95 | mtu00572: Arabinogalactan biosynthesis—Mycobacterium |
mtu00572: Arabinogalactan biosynthesis—Mycobacterium | Ethambutol |
| fbiC/fbiB | 9.49 | mtu01100: Metabolic pathways, mtu00680: Methane metabolism, mtu01120: Microbial metabolism in diverse environments |
mtu01100: Metabolic pathways, mtu01120: Microbial metabolism in diverse environments, mtu00680: Methane metabolism | Delamanid, Pretomanid |
| ddl/alr | 12.38 | mtu00470: D-Amino acid metabolism, mtu00550: Peptidoglycan biosynthesis, mtu01502: Vancomycin resistance, mtu01100: Metabolic pathways |
mtu01502: Vancomycin resistance, mtu01100: Metabolic pathways, mtu00470: D-Amino acid metabolism | Cycloserine, Terizidone |
| rpoC/rpoB | 14.21 | mtu03020: RNA polymerase | mtu03020: RNA polymerase | Rifabutin, Rifalazil, Rifampicin, Rifamycin, Rifapentine |
| rpoZ/rpoC | 14.63 | mtu03020: RNA polymerase | mtu03020: RNA polymerase | Rifabutin, Rifalazil, Rifampicin, Rifamycin, Rifapentine |
| rpoB/rpoA | 14.65 | mtu03020: RNA polymerase | mtu03020: RNA polymerase | Rifabutin, Rifalazil, Rifampicin, Rifamycin, Rifapentine |
| rplD/rplC | 15.30 | mtu03010: Ribosome | mtu03010: Ribosome | Linezolid, Sutezolid |
| rpoC/rpoA | 16.85 | mtu03020: RNA polymerase | mtu03020: RNA polymerase | Rifabutin, Rifalazil, Rifampicin, Rifamycin, Rifapentine |
| rpoZ/rpoB | 18.16 | mtu03020: RNA polymerase | mtu03020: RNA polymerase | Rifabutin, Rifalazil, Rifampicin, Rifamycin, Rifapentine |
| rpoZ/rpoA | 20.68 | mtu03020: RNA polymerase | mtu03020: RNA polymerase | Rifabutin, Rifalazil, Rifampicin, Rifamycin, Rifapentine |
| folC/ribD | 23.12 | mtu00790: Folate biosynthesis, mtu01240: Biosynthesis of cofactors, mtu01100: Metabolic pathways | mtu01240: Biosynthesis of cofactors, mtu02024: Quorum sensing, mtu00740: Riboflavin metabolism, mtu01100: Metabolic pathways, mtu01110: Biosynthesis of secondary metabolites | Aminosalicylic acid |
| glcB/menB | 25.86 | mtu01120: Microbial metabolism in diverse environments, mtu01200: Carbon metabolism, mtu00630: Glyoxylate and dicarboxylate metabolism, mtu01110: Biosynthesis of secondary metabolites, mtu01100: Metabolic pathways, mtu00620: Pyruvate metabolism | mtu01110: Biosynthesis of secondary metabolites, mtu00130: Ubiquinone and other terpenoid-quinone biosynthesis, mtu01240: Biosynthesis of cofactors, mtu01100: Metabolic pathways | Coenzyme A |
| fbiB/fbiA | 25.96 | mtu01100: Metabolic pathways, mtu01120: Microbial metabolism in diverse environments, mtu00680: Methane metabolism | mtu01240: Biosynthesis of cofactors, mtu01120: Microbial metabolism in diverse environments, mtu01100: Metabolic pathways, mtu00680: Methane metabolism | Delamanid, Pretomanid |
| fbiC/fbiA | 26.21 | mtu01100: Metabolic pathways, mtu00680: Methane metabolism, mtu01120: Microbial metabolism in diverse environments | mtu01240: Biosynthesis of cofactors, mtu01120: Microbial metabolism in diverse environments, mtu01100: Metabolic pathways, mtu00680: Methane metabolism |
Delamanid, Pretomanid |