Figure 1.
Summary of the main positive effects of SGLT2i drugs on the cardiovascular system. BNP: Pro-b-type natriuretic peptide; Ca: calcium; eNOS: endothelial nitric oxide synthase; K: potassium; Na: sodium; NHE1: sodium–hydrogen exchanger isoform 1; ROS: reactive oxygen species; SIRT1: nicotinammide adenina dinucleotide-dependent deacetylase sirtuin-1.