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. 2023 Sep 9;9(9):733. doi: 10.3390/gels9090733

Table 1.

A representative list of manufacturing technologies and related process variables used for HA dermal filler production.

Technology Manufacturer Product-by-Process Claims Patent Reference Literature Reference
Non-Animal Stabilized HA (NASHA®) Galderma
  • -

    sizing

 EP3013866B1 [5]
Optimal Balance Technology (OBT®)
  • -

    degree of crosslinking

  • -

    sizing

 WO2018104426A1 [11]
Hylacross® Allergan
  • -

    high proportion of high to low HA molecular mass

 US 8357795 B2 [13]
Vycross®
  • -

    high proportion of low to high HA molecular mass

 US 7741476 B2 [14]
Cohesive Polydensified Matrix (CPM®) Merz
  • -

    double HA addition

 EP1968711B1 [9]
Resilient HA (RHA®) Teoxane
  • -

    degree of crosslinking

  • -

    HA concentration

  • -

    reaction in pouch

 EP2429486B1 [10]