TABLE 2.
Agreement between results of HC II and PCR when HPV types other than those in the HC II Probe B cocktail were included
| Medium | HPV types detected by PCR | HC II cutoff (pg/ml) | % of specimens that were positive
|
Agreementc
|
|||
|---|---|---|---|---|---|---|---|
| HC II | PCRa | % Total | % Positive | Kappa value (95% CIs) | |||
| STM | HC II Probe B types plus related typesb | 0.2 | 13.9 | 91.8 | 59.5 | 0.70 (0.56, 0.83) | |
| 0.5 | 13.5 | 92.3 | 61.0 | 0.71 (0.58, 0.84) | |||
| 1.0 | 11.5 | 92.3 | 59.0 | 0.70 (0.56, 0.84) | |||
| All types | 0.2 | 13.9 | 85.6 | 45.5 | 0.54 (0.40, 0.68) | ||
| 0.5 | 13.5 | 86.1 | 46.3 | 0.56 (0.42, 0.69) | |||
| 1.0 | 11.5 | 86.1 | 44.2 | 0.54 (0.40, 0.68) | |||
| PC | HC II Probe B types plus related typesb | 0.2 | 22.1 | 18.3 | 84.6 | 44.8 | 0.52 (0.38, 0.67) |
| 0.5 | 15.9 | 18.3 | 88.0 | 47.9 | 0.58 (0.43, 0.72) | ||
| 1.0 | 13.0 | 18.3 | 88.9 | 47.7 | 0.58 (0.43, 0.73) | ||
| All types | 0.2 | 22.1 | 24.5 | 81.3 | 42.6 | 0.48 (0.34, 0.62) | |
| 0.5 | 15.9 | 24.5 | 84.6 | 44.8 | 0.53 (0.39, 0.67) | ||
| 1.0 | 13.0 | 24.5 | 84.6 | 41.8 | 0.51 (0.36, 0.65) | ||
a
The PCR test was done only on PC specimens.
b
HPV types considered genomically related to HC II Probe B types included HPVs 53, 66, 67, 70, and 73.
c
% Total, percentage of the total number of specimens tested by HC II and PCR that produced identical results; % Positive, percentage of specimens positive by either HC II or PCR that produced identical results.