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Describing the multi-complex of the VDR, comprising the receptor, co-receptors, co-repressors, co-activators, and pioneer factors that finally exert genomic effects on gene transcription. VDR: vitamin D receptor, RXR: retinoid acid receptor, PU.1, CEBPα, GABPα, ETS1, RUNX2, BACH2: pioneer factors, KDM1A, KDM6B: chromatin modifiers, BRD7, BRD9: chromatin remodelers, MED1: co-activator, NCOR2, COPS2: co-repressors.
