Table 3.
Effects of the amount of FCH on the changes in iron absorption and iron variables for 6 months.
| Time Course | F | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Iron Variable | FCH (mg) | M0 | M3 | M6 | FCH | Time | Interaction | |||
| Amounts | Course | Effects | ||||||||
| ΔFe2h, μg/dL | 750 | 23.0 | (37.5) | 18.5 | (36.6) | 17.2 | (28.0) | 7.58 * | 2.42 | 0.35 |
| 1500 | 29.9 | (37.1) | 29.6 | (35.3) | 29.1 | (36.2) | ||||
| 2250 | 25.6 | (44.9) | 27.8 | (50.2) | 21.2 | (46.5) | ||||
| FTN, ng/mL | 750 | 72.8 | (72.0) | 81.3 | (70.4) | 84.5 | (78.0) | 22.02 ** | 7.92 * | 0.168 |
| 1500 | 136.7 | (103.8) | 147.9 | (120.8) | 160.3 | (114.4) | ||||
| 2250 | 129.4 | (112.3) | 118.6 | (105.2) | 139.2 | (121.8) | ||||
| Hepcidin-25, ng/mL | 750 | 33.9 | (32.2) | 41.1 | (32.8) | 36.6 | (24.5) | 8.23 ** | 5.66 * | 0.78 |
| 1500 | 53.8 | (43.1) | 63.0 | (49.6) | 54.7 | (41.9) | ||||
| 2250 | 56.4 | (44.7) | 58.9 | (39.5) | 68.8 | (51.2) | ||||
| TSAT, % | 750 | 26.5 | (11.5) | 29.1 | (12.5) | 28.7 | (11.2) | 0.52 | 5.13 * | 0.60 |
| 1500 | 28.4 | (11.7) | 28.4 | (11.2) | 29.9 | (13.6) | ||||
| 2250 | 28.3 | (12.1) | 30.1 | (12.2) | 32.8 | (15.4) | ||||
| RBCs, 104/μL | 750 | 360.3 | (42.5) | 361.2 | (47.6) | 358.2 | (44.9) | 5.29 * | 0.38 | 0.71 |
| 1500 | 365.3 | (44.9) | 372.5 | (48.7) | 368.7 | (42.5) | ||||
| 2250 | 332.3 | (50.3) | 353.8 | (50.9) | 339.8 | (58.8) | ||||
| Hb, g/dL | 750 | 11.2 | (1.1) | 11.3 | (1.2) | 11.3 | (1.2) | 4.63 * | 5.87 * | 0.73 |
| 1500 | 11.4 | (1.2) | 11.6 | (1.4) | 11.6 | (1.1) | ||||
| 2250 | 10.6 | (1.5) | 11.3 | (1.4) | 11.1 | (1.5) | ||||
| MCH, pg/cell | 750 | 31.1 | (2.3) | 31.5 | (2.2) | 31.6 | (2.2) | 1.31 | 9.85 * | 0.91 |
| 1500 | 31.2 | (2.0) | 31.4 | (1.8) | 31.6 | (1.8) | ||||
| 2250 | 32.1 | (2.0) | 32.2 | (2.5) | 32.3 | (2.0) | ||||
| ESA, IU/week | 750 | 3701 | (3318) | 3231 | (3367) | 3015 | (3031) | 1.36 | 0.77 | 3.20 |
| 1500 | 3606 | (3477) | 3092 | (2738) | 3096 | (2773) | ||||
| 2250 | 3902 | (3901) | 4375 | (4134) | 4527 | (4052) | ||||
The obtained data are expressed as the mean ± standard deviation (SD). A two-way (amount × time) repeated measures ANOVA was used for the comparison of the data at M0, M3, and M6. When a significant difference was detected, a multiple comparison test was performed using the post hoc Bonferroni correction. The statistical significance was set at p < 0.05. FCH = 750 mg (n = 149); FCH = 1500 mg (n = 101); FCH 2250 mg (n = 18). FCH, ferric citrate hydrate; ΔFe2h, iron absorption in 2 h; FTN, ferritin; TSAT, transferrin saturation; RBCs, red blood cells; Hb, hemoglobin; MCH, mean corpuscular hemoglobin; ESA, erythropoiesis-stimulating agent. * p < 0.05. ** p < 0.001.