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. 2023 Sep 6;24(18):13770. doi: 10.3390/ijms241813770

Figure 7.

Figure 7

The interaction between endothelial and TNBC cells induces a proangiogenic secretome, which is suppressed by AZD4547. Results from the angiogenesis antibody array analysis showing the graphical color representation of the shift in the abundance of each factor in the secretome from co-cultures (CCs) after comparing against the secretome from endothelial monocultures (MCs). This effect is shown in the left column of the two TNBC cell lines, MBCDF-T and HCC1806, respectively (CCs vs. MCs). The change in the abundance of the angioregulatory factors in the secretome from CCs treated with the FGFR inhibitor AZD4547, compared against the CM of untreated CCs, is shown in the right column of each cell line (AZD4547). The red color indicates a rise in the abundance of each factor, whereas the green color indicates downregulation. The gray color depicts no change. As depicted, co-culturing endothelial cells with either TNBC cell line resulted in a general upregulation of proangiogenic factors as compared with the secretome from monocultured endothelial cells, while AZD4547 suppressed this effect.