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. 2023 Sep 6;24(18):13770. doi: 10.3390/ijms241813770

Figure 9.

Figure 9

The FGFR1/PI3K/Akt pathway is involved in TNBC cells VM capacity. The interaction of EA.hy926 cells with two different TNBC cell lines (a) HCC1806 or (b) MBCDF-T resulted in VM formation (Control). Incubation of these co-cultures in the presence of 5 µM AZD4547 or 6 µM LY294002 for 2 days prevented the formation of tubular-like structures. (c) Evaluation of the effect of each compound on VM morphometric parameters. The mean number of segments ± SEM is shown in black bars, while the mean number of meshes ± SEM is in gray bars. In (a,b), representative amplifications from 4× bright field images are shown. Scale bar is 100 μm. Two observers counted the segments and meshes per visual field in hot spots of at least three 4× magnification images. * p < 0.05 vs. control.