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. 2023 Sep 26;8(5):e1098. doi: 10.1097/PR9.0000000000001098

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Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.

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Figure 1. — Connection between chronic pain, central sensitization, and sleep disturbance. (A) Displayed are the so-far examined interrelations between migraine, evoked pain, sleep disturbances, and inhibitory pathways. (B) Displayed is the formation of the hypothesis for the present article. Although the interrelations between neuropathic pain and sleep disturbances and neuropathic pain and inhibitory pathways/central sensitization have been investigated, the effect of evoked pain on sleep disturbances remains unclear.