Table 3.

Regression results for associations between PGI and each cognitive domain, with age moderation, adjusting for sex, education, first PC, and brain measures. Standardized regression coefficients and their 95% confidence intervals are reported.

	(a) Memory			(b) Fluid Reasoning
Predictors	β	CI	p	β	CI	p
Cog PGI	0.082	[−0.105, 0.269]	0.387	0.275	[0.104, 0.446]	0.002
Age	−0.476	[−0.715, −0.236]	<0.001	−0.503	[−0.719, −0.287]	<0.001
Education	0.243	[0.099, 0.387]	0.001	0.119	[−0.011, 0.250]	0.072
Sex [M]	−0.288	[−0.615, 0.040]	0.085	−0.058	[−0.359, 0.242]	0.702
PC 1	−0.096	[−0.276, 0.083]	0.291	0.023	[−0.142, 0.188]	0.784
Cortical Thickness	0.081	[−0.120, 0.281]	0.427	−0.086	[−0.268, 0.096]	0.350
Total Gray Volume	−0.054	[−0.253, 0.145]	0.593	0.176	[−0.007, 0.359]	0.060
log(WMH + 1)	0.057	[−0.142, 0.257]	0.570	0.130	[−0.047, 0.306]	0.149
Cog PGI x Age	−0.147	[−0.288, −0.007]	0.040	−0.128	[−0.256, −0.001]	0.049
	(c) Speed of Processing			(d) Vocabulary
Predictors	β	CI	p	β	CI	p
Cog PGI	0.068	[−0.102, 0.239]	0.429	0.202	[0.041, 0.363]	0.014
Age	−0.655	[−0.871, −0.440]	<0.001	0.273	[0.073, 0.472]	0.008
Education	0.091	[−0.039, 0.221]	0.167	0.312	[0.192, 0.432]	<0.001
Sex [M]	−0.035	[−0.334, 0.264]	0.818	−0.161	[−0.442, 0.120]	0.259
PC 1	0.099	[−0.065, 0.264]	0.235	−0.015	[−0.168, 0.138]	0.848
Cortical Thickness	0.038	[−0.143, 0.220]	0.677	−0.055	[−0.229, 0.119]	0.536
Total Gray Volume	0.021	[−0.161, 0.204]	0.817	0.238	[0.068, 0.408]	0.006
log(WMH + 1)	0.070	[−0.106, 0.246]	0.436	−0.004	[−0.166, 0.158]	0.959
Cog PGI x Age	−0.096	[−0.223, 0.031]	0.138	−0.162	[−0.279, −0.044]	0.007

Note: Bold indicates a significant interaction effect between Cog PGI and age on the cognitive domains.