Figure 2.

Multitarget neuroprotective potential of Licochalcone A. Lico-A has the potential to exert a neuroprotective effect through a variety of mechanisms. It not only enhances cognitive activity via the BDNF-TrkB pathway but also displays antioxidant and anti-inflammatory properties by inhibiting microglia activation, thereby mitigating neuroinflammation. Furthermore, as an acetylcholinesterase inhibitor, Lico-A contributes to elevated levels of the neurotransmitter acetylcholine in the brain. Additionally, it plays a role in reducing the presence of amyloid plaques and neurofibrillary tangles (NFTs), further demonstrating its multifaceted approach to neuroprotection.