Table 3.
Changes in BMI, body weight, fasting glucose, insulin, and insulin resistance (HOMA-IR) (mean ± SD) in 21 obese PCOS women responsive (weight loss > 5%) to semaglutide treatment (0.5 mg subcutaneously once a week).
| Basal | After 3 Months of Treatment with Semaglutide | After 6 Months of Treatment with Semaglutide | |
|---|---|---|---|
| BMI (kg/m2) | 34.4 ± 5.9 | 30.8 ± 5 ** | 29.4 ± 5 ** |
| Body weight (kg) | 85 ±15 | 76 ± 16 ** | 73.5 ± 15 ** |
| Fasting glucose (mg/dL) | 97 ± 12 | 90 ± 8 ** | 90 ± 6 ** |
| Insulin (mU/mL) | 17 ± 7 | 11 ± 5 ** | 11 ± 5 ** |
| HOMA-IR | 3.5 ± 2 | 2.5 ± 1 ** | 2.4 ± 0.8 ** |
** p < 0.01 versus basal values.