Table 1.
Baseline demographic and clinical characteristics, clinical and laboratory data on Intermediate Respiratory Care Unit admission and clinical outcomes of patients switched to High Flow Nasal Cannula.
| Patient, No. | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
|---|---|---|---|---|---|---|---|---|---|
| Baseline demographic and clinical data | |||||||||
| Age, years | 61 | 30 | 73 | 53 | 21 | 56 | 34 | 45 | 34 |
| Gender | F | M | M | F | M | M | M | M | F |
| Body mass index, kg/m2 | 20.2 | 14.6 | - | 30.5 | 30.1 | - | 15 | - | 31.2 |
| Smoking habit | Ex-smoker | Non-smoker | Non-smoker | Non-smoker | Non-smoker | Ex-smoker | Non-smoker | Non-smoker | Non-smoker |
| PEG tube | yes | no | no | no | no | no | no | yes | no |
| Type of NMD | ALS | CM | ALS | DM1 | DMD | Type II SMA | Unspecified myopathy | ALS | AP |
| Comorbidity | Breast cancer | Testicular seminoma | - | Calculous cholecystitis | OSA | CHF diabetes |
Hypertension | - | AATD |
| Clinical, laboratory and ABG data on IRCU admission | |||||||||
| Diagnosis related to ARF | Pneumonia | Pneumonia | Pneumonia | Interstitial pneumonia | PNX | Undernutrition | Pneumonia | Pneumonia, Atelectasis | Bronchiectasis exacerbation |
| HR, beats/min | 91 | 79 | 120 | 69 | 100 | 83 | 102 | 105 | 62 |
| RR, breaths/min | 25 | 17 | 23 | - | 20 | - | 15 | - | 20 |
| White blood cell count, ×109/L | 4.09 | 14.84 | 12.02 | 7.09 | 7.43 | 7.21 | 9.08 | 17.9 | 7.7 |
| Serum CRP, μg/ml | 8.67 | 205 | 102 | 5.48 | 20.04 | 13 | 3.18 | 94 | 0,6 |
| PaO2, mmHg | 80.9 * | 57.4 | 167 * | 64.3 | 57.5 | 56.2 | 81 | 132 * | 92.8 * |
| PaCO2, mmHg | 41.8 | 41.3 | 74 | 54.1 | 57.4 | 60.7 | 60 | 44.5 | 33.9 |
| pH | 7.43 | 7.47 | 7.32 | 7.39 | 7.38 | 7.28 | 7.45 | 7.45 | 7.44 |
| PaO2/FiO2, mmHg | 155.6 | 239.1 | 208.7 | 207.4 | 273.8 | 175.6 | 289.2 | 368.1 | 386.7 |
| Clinical outcomes | |||||||||
| ETI, trach, discharged | Discharged | ETI, trach, discharged | Discharged | Discharged | Discharged | Discharged | Died | Discharged |
* Supplemental O2. AATD = Alpha 1 Antitrypsin Deficiency; ABG = Arterial Blood Gas; AHF = Acute Heart Failure; ALS = Amyotrophic Lateral Sclerosis; AP = Axonal Polyneuropathy; CHF = Chronic Heart Failure; CM = Congenital Myopathy; DM1 = Myotonic Dystrophy Type 1 DMD = Duchenne’s Muscular Dystrophy; HFNC = High Flow Nasal Cannula; IRCU = Intermediate Respiratory Care Unit; NIV = Non-Invasive Ventilation; NMD = Neuromuscular Disease; OSA = Obstructive Sleep Apnea; PEG = Percutaneous Gastrostomy; PNX = Pneumothorax; Trach = tracheostomy.