Table 2.
Causes of Non-Invasive Ventilation intolerance, High Flow Nasal Cannula use and PaCO2 outcomes.
| Patient, No. | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
|---|---|---|---|---|---|---|---|---|---|
| Cause of NIV intolerance | Claustrophobia | Uncooperative | Agitation | Difficulty eating | Agitation | Difficulty eating | Difficulty eating | Dry mouth | Thoracic pain |
| Time to switch, h | 0.5 | 0.5 | 1 | 15 | 48 | 36 | 25 | 64 | 25 |
| HFNC use | 24 h a day | Daytime | 24 h a day | Daytime | Daytime | Daytime | Daytime | 24 h a day | Daytime |
| PaCO2 at switch time, mmHg | 43 | 38.7 | 68.1 | 59.2 | 65.8 | 56.5 | 62.5 | 56.6 | 41 |
| PaCO2 at 2 h interval, mmHg (HFNC flow rate, L/min—FIO2) | 41.3 (60–0.6) |
45.6 (50–0.4) |
67 (40–0.4) |
51 (60–0.4) |
65.9 (30–0.3) |
60.4 (60–0.73) |
64.8 (60–0.21) |
55.6 (60–0.3) |
36.9 (60–0.38) |
| PaCO2 at 12 h interval, mmHg (HFNC flow rate, L/min—FIO2) |
46.6 (60–0.52) |
39.1 (50–0.3) |
61 (NA) |
51 (60–0.8) |
64 (30–0.3) |
57.1 (NA) |
59.3 (60–0.21) |
41.5 (NA) |
33.6 (50–0.27) |
HFNC = High Flow Nasal Cannula; NA = Not available; NIV = Non-Invasive Ventilation.