Figure 3.

Potential benefits of L-Carnitine supplementation for male fertility In vitro studies with Sertoli cells suggest that L-Carnitine has a role in the metabolism—regulating other functions in these cells related to germ cell nutrition, which leads to an improvement in semen quality. Consistently, clinical trials with infertile men and in vivo studies report that when given L-Carnitine supplementation, there is an increase in sperm parameters, such as concentration, motility, and morphology, a modulation of ROS production, and an increase in antioxidant enzyme expression, such as SOD and CAT. Collectively, these findings suggest that L-Carnitine possesses the potential to wield favorable effects on male infertility. Further exploration is necessary to unravel the intricate mechanisms that underlie these transformative effects. NEFA—Non-esterified fatty acid; LT—Lactate; CAT—Catalase; SOD—Superoxide dismutase; GR—Glutathione Reductase; GST—Glutathione S-Transferase.