Table 1.
Demographic, clinical and MRI data at the baseline MRI.
| Variable | All Patients (N = 813) |
Patients without Arrhythmias (N = 793) |
Patients with Arrhythmias (N = 20) |
p-Value |
|---|---|---|---|---|
| Females, N (%) | 444 (54.6) | 438 (55.2) | 6 (30.0) | 0.025 |
| Age (yrs) | 36.47 ± 10.71 | 36.27 ± 10.72 | 44.47 ± 6.81 | <0.0001 |
| Splenectomy, N (%) | 449 (55.2) | 435 (54.9) | 14 (70) | 0.179 |
| Pretransfusion hemoglobin (g/dL) | 9.67 ± 0.55 | 9.67 ± 0.55 | 9.68 ± 0.54 | 0.965 |
| Serum ferritin (ng/L) | 1061.24 ± 1330.85 | 1066.71 ± 1336.84 | 860.62 ± 1099.31 | 0.059 |
| Diabetes, N (%) | 89/796 (11.2) | 83/776 (10.7) | 6/20 (30.0) | 0.007 |
| MRI LIC (mg/g/dw) | 5.88 ± 8.72 | 5.79 ± 8.52 | 9.02 ± 14.50 | 0.556 |
| Global pancreas T2* (ms) | 13.16 ± 10.49 | 13.32 ± 10.54 | 6.79 ± 5.11 | 0.001 |
| Global heart T2* (ms) | 37.32 ± 9.40 | 37.33 ± 9.38 | 36.77 ± 10.45 | 0.977 |
| N. of segments with T2* < 20 ms | 1.49 ± 4.06 | 1.49 ± 4.06 | 1.40 ± 3.89 | 0.792 |
| LV EDVI (mL/m2) | 82.15 ± 16.84 | 82.14 ± 16.67 | 82.59 ± 24.00 | 0.845 |
| LV EF (%) | 62.41 ± 6.59 | 62.38 ± 6.61 | 63.88 ± 5.43 | 0.335 |
| LV mass index (g/m2) | 54.81 ± 13.43 | 54.76 ± 13.44 | 57.18 ± 12.68 | 0.410 |
| RV EDVI (mL/m2) | 80.34 ± 17.63 | 80.34 ± 17.48 | 80.06 ± 23.97 | 0.436 |
| RV EF (%) | 60.86 ± 7.09 | 60.79 ± 7.09 | 62.59 ± 6.34 | 0.076 |
| Replacement myocardial fibrosis, N (%) | 56/224 (25.0) | 54/218 (24.8) | 2/6 (33.3) | 0.633 |
| Left atrial area (cm2/m2) | 12.89 ± 2.50 | 12.82 ± 2.43 | 15.36 ± 3.69 | 0.002 |
| Right atrial area (cm2/m2) | 11.85 ± 2.38 | 11.79 ± 2.29 | 13.75 ± 3.95 | 0.014 |
N = number, MRI = magnetic resonance imaging, LIC = liver iron concentration, LV = left ventricular, EDVI = end-diastolic volume index, EF = ejection fraction, and RV = right ventricular.