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. 2023 Sep 19;24(18):14274. doi: 10.3390/ijms241814274

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Epidermal stem cell heterogeneity in human and mouse skin. Stem cells are illustrated in dark or light green (dark green for slow-cycling stem cells and light green for fast-cycling stem cells) with some of their respective gene expression markers in boxed regions [134,135]. Fibulin 7 matricellular protein is localized in the basement membrane (BM) to support epidermal stem cell heterogeneity during skin aging. Other matricellular proteins regulating the BM, epidermal stem cells homeostasis, and the re-epithelialization process in injury-induced regeneration are summarized in Table 1 and Table 3. Created with BioRender.com (accessed on 22 July 2023).