Figure 1.
Aβ accumulation is present in the retinal blood vessels from 4 M and 12 M 5xFAD retinas and sporadically in the 12 M WT retinas. (A–D) The expression of Aβ in the retinal blood vessels from WT and 5xFAD mice was analyzed using immunohistochemistry. Co-localization was observed in the blood vessels from 4 M (B) and 12 M (D) 5xFAD retinas (arrows) and sporadically in the 12 M WT retinas (anti-Aβ, 6E10—red, lectin—green, DAPI—blue). Scale bar—50 μm. ONL—outer nuclear layer. INL—inner nuclear layer.