Table 1.
Reference table of Drosophila melanogaster DM2 models.
| Pathogenic Mechanism | Drosophila Model | Affected Tissue | Phenotype | Ref |
|---|---|---|---|---|
| Loss of function | UAS-CNBPRNAi | Muscle (c179-G4; How24B-G4; Mef-G4, Mhc-G4) | Locomotion Climbing |
[13] |
| RNA toxicity | UAS-CCTG16 | Eye (GMR-G4), Muscle (How24B-G4), Nervous system (elav-G4) |
Eye degeneration | |
| UAS-CCTG200 | Muscle RNA foci | [68] | ||
| UAS-CCTG475 | ||||
| UAS-CCTG525 | ||||
| UAS-CCTG700 | ||||
| UAS-CCTG720 | ||||
| Missplicing | [69] | |||
| UAS-CCTG106 | Muscle (Mhc-G4) Eye (GMR-G4) |
Apoptotic response | ||
| UAS-CCTG480 | ||||
| Autophagy | ||||
| UAS-CCTG20 | Muscle (Mhc-G4) Heart (GMH5-G4) |
Muscle degeneration | [58] | |
| UAS-CCTG1100 | Reduced survival | |||
| Locomotor defects |