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Chronically administered 8-OH-DPAT halts T1DM-induced neuronal degeneration. 8-hydroxy-2-(dipropylamino)tetralin (0.5 mg/kg) was administered i.p. on a daily basis for 14 days. Hematoxylin and Eosin staining of LSSC (A–C) and DRG (D–F), respectively (magnification: 40× and scale bar: 20 µm). Abbreviations: NC—normal control, T1DM—type 1 diabetes mellitus, LSSC—lumbar segment of the spinal cord, DRG—dorsal root ganglia and 8-OH-DPAT—8-hydroxy-2-(dipropylamino)tetralin.
