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. 2023 Sep 20;24(18):14334. doi: 10.3390/ijms241814334

Figure 7.

Figure 7

Chronically administered 8-OH-DPAT reverses T1DM-induced upregulation of Ido1, Ido2 and Tdo but not Tph-2, in the spinal cord lumbar region. Expression of Tph-2 (A), Ido1, Ido2 and Tdo (B) were quantified at mRNA levels using qRT-PCR. 8-hydroxy-2-(dipropylamino)tetralin (0.5 mg/kg) was injected i.p. daily for 14 days. Each bar represents the mean ± SEM of values obtained from five animals/group. * Diabetic animals were significantly different from corresponding control values at p ≤ 0.05. ** 8-OH-DPAT-treated diabetic animals were significantly different from corresponding diabetic animals at p ≤ 0.05. One-way ANOVA followed by Dunnett’s post-test. Abbreviations: NC—normal control, T1DM—type 1 diabetes mellitus, RVM—rostral ventromedial medulla, LSSC—lumbar segment of the spinal cord, DRG—dorsal root ganglia, Tph-2—tryptophan hydroxylase-2, IDO—indoleamine 2,3-dioxygenase, TDO—tryptophan 2,3-dioxygenase and 8-OH-DPAT—8-hydroxy-2-(dipropylamino)tetralin.