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. 2023 Sep 20;24(18):14334. doi: 10.3390/ijms241814334

Figure 9.

Figure 9

Schematic representation of presynaptic 5-HT1AR in STZ-induced T1DM, neuropathic pain and 8-OH-DPAT administration. When compared to the control status (A), diabetes enhances neuronal presynaptic expression of 5-HT1AR in the RVM, LSSC and DRG (B). 8-OH-DPAT administered chronically for 14 days reversed increased neuronal expression of presynaptic 5-HT1AR in this disease state (C). The upward arrow indicates the ascending pain transmission pathway, while the downward arrow indicates the descending pain transmission pathway. Pain in the red bubble indicates pain aggravation, and pain in the green bubble indicates pain alleviation. The thick and thin arrows in (B) represent hyperactive ascending pathways and hypoactive descending pathways. Abbreviations: 8-OH-DPAT—8-hydroxy-2-(dipropylamino)tetralin, 5-HT1AR—5-HT1A receptors, RVM—rostral ventromedial medulla, LSSC—lumbar segment of the spinal cord and DRG—dorsal root ganglia.