Table 1.

8-hydroxy-2-(dipropylamino)tetralin dependent changes in LSSC 5-HT metabolism STZ-induced T1DM.

Treatment	5-HIAA (ng/mL)	5-HT (ng/mL)	5-HIAA/5-HT (ng/mL)
NC	12.0 ± 0.302	14.1 ± 0.364	0.854 ± 0.03
T1DM	10.6 ± 0.484 *	18.3 ± 0.510 *	0.578 ± 0.03 *
T1DM + 8-OH-DPAT	11.5 ± 0.06	16.7 ± 0.843	0.689 ± 0.03 **

Each bar represents the mean ± SEM of values obtained from five animals/group. * Diabetic animals were significantly different from corresponding control values at p ≤ 0.05. ** 8-OH-DPAT-treated diabetic animals were significantly different from corresponding diabetic animals at p ≤ 0.05. One-way ANOVA followed by Dunnett’s post-test. Abbreviations: 5-HT—5-hydroxytryptamine or serotonin, 5-HIAA—5-hydroxyindole acetic acid, NC—normal control, T1DM—type 1 diabetes mellitus, LSSC—lumbar segment of the spinal cord and 8-OH-DPAT—8-hydroxy-2-(dipropylamino)tetralin.