Table 3.

Summary of results.

T1DM	Effects of Chronic 8-OH-DPAT (0.5 mg/kg, i.p.) Administration
↓ Pain threshold	↑ Pain threshold
Neuronal degeneration (LSSC and DRG)	Improved neuronal degeneration (LSSC and DRG)
↓ 5-HT1AR mRNA and protein expression (RVM, LSSC and DRG)	↑ 5-HT1AR mRNA and protein expression (RVM, LSSC and DRG)
↑ Presynaptic 5-HT1AR	↓ Presynaptic 5-HT1AR
↑ Gαi	↓ Gαi
↑ Tph-2 mRNA (RVM, LSSC and DRG)	No change in Tph-2 mRNA (RVM, LSSC and DRG)
↑ Tdo/Ido-1/2 mRNA (LSSC)	↓ Tdo/Ido-1/2 mRNA (LSSC)
↓ 5-HIAA/5-HT (LSSC)	↑ 5-HIAA/5-HT (LSSC)
↑ QA (LSSC)	↓ QA (LSSC)

↑ means increased, while ↓ means decreased.