Table 1.

Comparison among glucagon-like peptide 1-receptor agonists.

Drug	Route of Administration	Frequency	Dose (mg)	Half-Life Time	Weight Loss	Cardiovascular Benefits	↓ HbA1c
Exenatide	sc	twice daily	5–10	2.4 h	++	No	++
Lixisenatide	sc	once daily	10–20	3 h	+	No	++
Liraglutide	sc	once daily	0.6–1.8	13 h	+++	Yes	++
Dulaglutide	sc	once weekly	0.75–1.5	5 days	++	Yes	++
Semaglutide	sc	once weekly	0.25–1	1 week	+++	Yes	+++
	oral	once daily	3–14	1 week	+++	Yes	+++

sc—subcutaneous. (+)—positive effect, (++)—strong positive effect, (+++)—very strong positive effect.