Table 3.
Growth and puberty parameters at most recent visit.
| Genotype | Deletion | Non-Deletion | Total Group | N |
|---|---|---|---|---|
| Height SDS (SD) | −1.23 (1.4) | −1.13 (1.1) | −1.19 (1.3) | 144 |
| UPD | −1.18 (1.4) | |||
| ICD | −1.24 (1.0) | |||
| UBE3A | −1.07 (1.0) | |||
| BMI-SDS (SD) * | 0.37 (1.7) | 1.03 (1.5) | 0.63 (1.7) | 135 |
| UPD | 1.43 (1.4) | |||
| ICD | 0.83 (1.7) | |||
| UBE3A | 0.82 (1.5) | |||
| BMI ≥ 1 SDS (N (% of subgroup)) * | 25 (30) | 33 (62) | 58 (43) | |
| Overweight (BMI ≥ 1–<2 SDS) (N (% of subgroup)) * | 10 (12) | 21 (40) | 31 (23) | |
| Obesity (BMI ≥ 2 SDS) (N (% of subgroup)) | 15 (18) | 12 (22) | 27 (20) | 135 |
| Target height SDS (SD) | 0.20 (0.1) | 0.06 (0.1) | 0.07 (0.87) | 133 |
| Height—Target height SDS (SD) | −1.32 (1.4) | −1.26 (1.1) | −1.30 (1.3) | 133 |
| Age at menarche in years (SD) | 11.8 (2.4) | 11.4 (1.2) | 11.6 (1.9) | 25 |
| Onset of puberty (N (% of subgroup)) | ||||
| Prepubertal | 41 (46) | 18 (32) | 59 (41) | |
| Early | 3 (3) | 0 | 3 (2) | |
| Normal | 40 (45) | 31 (55) | 71 (49) | |
| Late | 5 (6) | 7 (13) | 12 (8) | 145 |
UPD = uniparental paternal disomy, ICD = imprinting center defect. * Significant difference between deletion and non-deletion (BMI-SDS p = 0.037, BMI-SDS > 1 p < 0.001, overweight p < 0.001).