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The EGFR/EGFRvIII pathway contributes to the progression of GBM. While PI3K and RAS/MAPK activation is stronger in EGFRvIII-expressing cells, EGFRwt commonly stimulates MAPK and STAT3, encouraging tumor growth. Meanwhile, EGFRvIII is constitutively activated and primarily initiates the PI3K pathway, which is involved in tumor invasion and survival.
