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The role of GBM heterogeneity in GBM recurrence. In addition to patient variability, the cells within the tumor may belong to different subpopulations and carry a variety of active molecular processes. An untargeted process in cell (A) may trigger survival molecular mechanisms in cell (B) via soluble factors, resulting in the emergence of a new resistant subpopulation and tumor progression. Cell (C) represents another innately resistant subpopulation.
