Figure 1.

Hemodynamic changes in patients with severe mitral regurgitation: increased left ventricular pressure, backward blood flow from the left ventricle to the left atrium leading to elevation of the left atrium pressure. The latter is passively transmitted to pulmonary veins and pulmonary circulation leading to pulmonary hypertension. Red arrow: passive backward pressure transmission from pulmonary veins to pulmonary circulation 🡪 PASP elevation, Red-black arrow: backward blood flow, Blue arrows: increased left ventricular filling pressure, PASP: pulmonary artery systolic pressure, LAP: left atrial pressure, LVFP: LV filling pressure.