Table 4.
MIC values of the leading repositionable compounds ebselen, temsirolimus, and BAY 11-7082 against multiple clinical isolates belonging to different species of filamentous fungi, in comparison to voriconazole and/or posaconazole. Values are in μg/mL.
| Species | Isolate | Ebselen | Temsirolimus | BAY 11-7082 | Voriconazole | Posaconazole | |||
|---|---|---|---|---|---|---|---|---|---|
| 50% | 100% | 50% | 100% | 50% | 100% | 100% | 100% | ||
| P. variotii QC | MYA-3630 | 4 | 4 | 16 | >32 | 1 | 1 | 0.125 | ≤0.03 |
| Rhizopus arrhizus | Rh-1 | 4 | >32 | >32 | >32 | 4 | 4 | - | 1 |
| Rh-2 | 8 | >32 | >32 | >32 | 4 | 4 | - | 0.5 | |
| Rh-3 | 2 | >32 | >32 | >32 | 0.5 | 1 | - | 0.5 | |
| Mucor spp. | Mu-1 | 8 | >32 | >32 | >32 | 4 | 4 | - | 2 |
| Mu-2 | 8 | >32 | >32 | >32 | 2 | 4 | - | 1 | |
| Mu-3 | 4 | >32 | 0.125 | >32 | 2 | 4 | - | 2 | |
| Aspergillus flavus | ATCC204304 | 4 | 4 | >32 | >32 | 4 | 4 | 1 | - |
| Afl-1 | 4 | 4 | >32 | >32 | 2 | 4 | 1 | - | |
| Afl-2 | 4 | 4 | >32 | >32 | 2 | 4 | 1 | - | |
| Aspergillus fumigatus | AF293 | 4 | 4 | >32 | >32 | 1 | 1 | 0.5 | - |
| Af-1 | 4 | 4 | >32 | >32 | 1 | 1 | >16 | - | |
| Af-2 | 4 | 4 | >32 | >32 | 1 | 1 | 4 | - | |
| Fusarium spp. | Fu-1 | 4 | 4 | 2 | >32 | 1 | 1 | >16 | - |
| Fu-2 | 4 | 8 | 2 | >32 | 0.5 | 1 | >16 | - | |
| Fu-3 | 4 | 8 | 1 | >32 | 1 | 2 | >16 | - | |
| Lomentospora prolificans | Sc-1 | 4 | 8 | 0.5 | >32 | 0.5 | 0.5 | >16 | - |
| Scedosporium spp. | Sc-2 | 4 | 4 | 1 | >32 | 0.5 | 0.5 | 2 | - |
| Sc-3 | 2 | 2 | 0.5 | >32 | 0.25 | 0.5 | 1 | - | |
| Altenaria | Al-1 | 0.5 | 2 | >32 | >32 | 0.5 | 1 | 1 | - |
| Curvularia | Cu-1 | 1 | 2 | 16 | >32 | 0.5 | 1 | 0.5 | - |
| Exserohilum | Ex-1 | 1 | 4 | 16 | >32 | 0.5 | 1 | 2 | - |