Table 4.

Univariable and multivariable analysis for NO₂ exposure related to CAD progression.

	Univariable			Multivariable
	OR	95% CI	p	OR	95% CI	p
Demographical factors:				-	-	-
Sex	1.24	0.42–1.84	<0.001 *
Age	1.05	0.10–1.13	0.055
Co-morbidities				-	-	-
Arterial hypertension	5.43	0.42–29.63	0.009 *
DM	2.83	0.01–2.92	0.073
Hyperlipidemia	2.65	0.50–14.55	<0.001 *
Thyroid disease	1.99	0.14–1.15	0.418
Laboratory results:				-	-	-
WBC	0.66	0.03–0.21	0.197
Hemoglobin	2.06	0.61–2.05	0.286
NLR	1.09	0.77–1.09	0.557
MLR	4.83	1.67–4.82	0.342
SIRI	2.23	1.14–2.74	0.42
MCHC	0.77	0.61–2.43	0.243
Creatinine	1.01	0.03–0.53	0.486
Ureic acid	1	0.03–1.02	0.734
Air pollution—PM < 2.5				-	-	-
PM < 2.5 in 2019	0.98	0.796–1.722	0.859
PM < 2.5 in 2020	4.13	0.23–6.42	<0.001
PM < 2.5 in 2021	1.53	0.20–6.58	<0.001
Mean PM < 2.5 exposure	1.44	0.21–5.17	<0.001
Max PM < 2.5 exposure	1.15	0.01–2.76	0.033
Air pollution—PM < 10				-	-	-
PM < 10 in 2019	1.39	0.20–4.55	<0.001
PM < 10 in 2020	1.43	0.23–4.87	<0.001
PM < 10 in 2021	1.28	0.13–3.55	<0.001
Mean PM < 10 exposure	1.44	0.23–5.01	<0.001
Max PM < 10 exposure	1.33	0.17–4.04	<0.001
Air pollution—NO2
NO2 in 2019	1.57	0.33–5.80	<0.001
NO2 in 2020	1.99	0.49–8.80	<0.001
NO2 in 2021	2.35	0.61–1.10	<0.001
Mean	1.93	0.48–8.45	<0.001	2	0.41–9.62	<0.001
Max	1.76	0.41–7.27	<0.001

Abbreviations: DM, diabetes mellitus; max, maximum; MCHC, mean corpuscular hemoglobin concentration; NO₂, nitrogen oxides; OR, odds ratio; RDW, red cells distribution width; WBC, white blood count. * statistically significant.