Table 2.
Multivariable Cox analysis for incident hypertension according to changes in proteinuria status.
| Group | Total (n) | Hypertension (n) | Incidence Rate (per 1000 Person Years) | HR (95% Confidence Interval) | ||
|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | ||||
| Proteinuria-free | 919,044 | 339,260 | 31.5 | 1 (ref) | 1 (ref) | 1 (ref) |
| Proteinuria-resolved | 7488 | 3131 | 37.4 | 1.19 (1.15, 1.23) | 1.17 (1.13, 1.21) | 1.17 (1.13, 1.21) |
| Proteinuria-developed | 8205 | 3638 | 41.3 | 1.31 (1.27, 1.35) | 1.31 (1.27, 1.35) | 1.31 (1.26, 1.35) |
| Chronic proteinuria | 986 | 657 | 81.4 | 2.61 (2.41, 2.81) | 2.11 (1.95, 2.27) | 2.09 (1.94, 2.26) |
| p for trend | <0.001 | <0.001 | <0.001 | |||
Model 1 was adjusted for age and sex. Model 2 was adjusted for age, sex, body mass index, household income, smoking, alcohol consumption, physical activity, history of diabetes mellitus, dyslipidemia, atrial fibrillation, cancer, and renal disease. Model 3 was adjusted for age, sex, body mass index, household income, smoking, alcohol consumption, physical activity, history of diabetes mellitus, dyslipidemia, atrial fibrillation, cancer, renal disease, and Charlson Comorbidity Index. HR, hazard ratio; CI, confidence interval.