Table 1.
Important omics databases related to the drug combination.
| Data Type | Database | URL | Latest Update | Description |
|---|---|---|---|---|
| Synergistic Drug Combination | DrugComb [21] | https://drugcomb.fimm.fi/ (accessed on 13 July 2023) | 2021 | Synergistic Drug Combination mainly contains data on the response of cancer cell lines to or combinations of drugs. |
| DrugCombDB [22] | http://drugcombdb.denglab.org/ (accessed on 13 July 2023) | 2019 | ||
| NCI-ALMANAC [23] | https://dtp.cancer.gov/ncialmanac (accessed on 13 July 2023) | 2017 | ||
| SYNERGxDB [24] | https://www.synergxdb.ca/ (accessed on 13 July 2023) | 2019 | ||
| Bioactivity resources | ChEMBL [25] | https://www.ebi.ac.uk/chembl/ (accessed on 13 July 2023) | 2023 | Bioactivity resources mainly contain the biological activity data of small molecules, drug targets, enzymes and proteins. |
| DrugBank [26] | https://www.drugbank.com (accessed on 14 July 2023) | 2023 | ||
| PubChem [27] | https://pubchem.ncbi.nlm.nih.gov (accessed on 14 July 2023) | 2023 | ||
| Gene expression | GEO [28] | https://www.ncbi.nlm.nih.gov/geo/ (accessed on 14 July 2023) | 2013 | It mainly includes gene expression data with or without perturbation, gene methylation data and some interaction data. |
| CMap [29] | https://clue.io (accessed on 14 July 2023) | 2021 | ||
| LINCS | https://lincsproject.org/ (accessed on 14 July 2023) | 2022 | ||
| Toxicity effects resources | SIDER [30] | http://sideeffects.embl.de/ (accessed on 15 July 2023) | 2015 | Toxicity effects resources mainly contain information about drugs and targets, as well as information on side effects. |
| TOXRIC [31] | https://toxric.bioinforai.tech/ (accessed on 15 July 2023) | 2022 | ||
| Tox21BodyMap [32] | https://sandbox.ntp.niehs.nih.gov/bodymap/ (accessed on 15 July 2023) | 2020 | ||
| Pathways resources | Reactome [33] | https://reactome.org/ (accessed on 15 July 2023) | 2023 | Pathways resources mainly contain various biological pathways that facilitate drug combination prediction. |
| Pathbank [34] | https://pathbank.org/ (accessed on 15 July 2023) | 2020 | ||
| KEGG Pathways [35] | https://www.kegg.jp/kegg/pathway.html (accessed on 15 July 2023) | 2023 | ||
| Interactions resources | TTD [36] | https://db.idrblab.net/ttd/ (accessed on 16 July 2023) | 2023 | It mainly contains information about drug targets and targeted drugs that interact with them. |
| Bingding DB [37] | http://www.bindingdb.org (accessed on 16 July 2023) | 2023 | ||
| HPRD [38] | http://www.hprd.org/ (accessed on 16 July 2023) | 2008 | ||
| STRING [39] | https://string-db.org/ (accessed on 16 July 2023) | 2021 | ||
| STITCH [40] | http://stitch.embl.de/ (accessed on 16 July 2023) | 2016 |