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. 2023 Sep 20;621(7980):857–867. doi: 10.1038/s41586-023-06549-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a and b, Hyperosmotic (a) and hypoosmotic (b) ALI culture conditions induce ionocyte expansion. Ionocytes were localized either by lineage tracing using FOXI1-Cre^ERT2 or ATP6V1G3 staining. Representative images of cultures derived from n = 5 donor ferrets for hyperosmotic stress and n = 4 ferrets for hypoosmotic stress. c and d, Additional panels related to Extended Data Fig. 7k. Whole mount trachea immunostaining demonstrating expanding ATP6V1G3⁺ ionocytes in KRT5⁺-enriched submucosal gland (SMG) ducts and NKA⁺ tubules of CFTR^G551D/G551D ferrets (reared off VX-770). Confocal Z planes are indicated and show apical surface to SMG planes (c) or just the SMG plane (d). DO, duct opening. Representative images from n = 3 CF ferrets.